Edyta Koscianska. Vesselin Baev. Konstantinia Skreka. Katerina Oikonomaki. Ventsislav Rusinov. Martin Tabler and Kriton Kalantidis
MicroRNAs (miRNAs) are one of the most abundant groups of regulatory genes in multicellular organisms playing important roles in many fundamental cellular processes. More than four hundred miRNAs undergo been identified in humans and the deregulation of miRNA expression has been also shown in many cancers. Despite the postulated involvement of miRNAs in tumourigenesis there are only a few examples where an oncogene or a tumour suppressor has been identified as a miRNA target.
Here we present an in silico analysis of potential miRNA- oncogene interactions. Moreover we have tested the validity of two possible interactions of miRNAs with genes related to cancer. We show evidence for the down-regulation of c-MYC one of the most potent and frequently deregulated oncogenes by let-7 miRNA via the predicted binding site in the 3UTR and affirm the suppression of BCL-2 by miR16.
In this bring home the bacon both bioinformatic and experimental approaches for the prediction and validation of possible targets for miRNAs have been used. A list of putative targets for different oncomirs validation of which would be of special arouse is proposed and two such interactions undergo been experimentally validated.
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Related article:
http://www.biomedcentral.com/1471-2199/8/79
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